神戸市中央区の内科 糖尿病専門内科 上野内科・糖尿病内科クリニック

院長の業績

Publication list

1. Contribution of Leptin to Energy Expenditure and Glucose Metabolism in Fasting.

Ueno N, Asakawa A, Inui A.

Journal of Endocrinology, Diabetes & Obesity. 2016 4(2)


2. The enhanced effect of atenolol on hypertension in metabolic syndrome.

Ueno N, Satou Y.

Metab Syndr Relat Disord. 2011 Oct;9(5):369-73. Epub 2011 Jun 6.


3. The effect of mosapride citrate on constipation in patients with diabetes.

Ueno N, Inui A, Satoh Y.

Diabetes Res Clin Pract. 2010 Jan;87(1):27-32. Epub 2009 Nov 3.


4. Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice.

Kojima S, Asakawa A, Amitani H, Sakoguchi T, Ueno N, Inui A, Kalra SP.

Peptides. 2009 May;30(5):962-6. Epub 2009 Jan 22.


5. Rapid effect of mosapride citrate, 5-HT4 receptor agonist, on fasting blood glucose in Type 2 diabetes patients.

Ueno N, Satoh Y.

J Diabetes Complications. 2009 Jul-Aug;23(4):255-6. Epub 2008 Apr 16. No abstract available.


6, Anorexic peptides

Perboni S, Ueno N, Mantovani G, and Inui A.

Peptides in Energy Balance and Obesity. 2009 Part1(2):33-60


7, Blunted metabolic response to fasting in obese mice.

Ueno N, Asakawa A, Inui A.

Endocrine. 2007 Oct;32(2):192-6. Epub 2007 Nov 2.


8. Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development.

Yuzuriha H, Inui A, Asakawa A, Ueno N, Kasuga M, Meguid MM, Miyazaki J, Ninomiya M, Herzog H, Fujimiya M.

FASEB J. 2007 Jul;21(9):2108-12. Epub 2007 Mar 30.


9. Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide.

Ueno N, Asakawa A, Satoh Y, Inui A.

Regul Pept. 2007 Jun 7;141(1-3):8-11. Epub 2007 Jan 11.


10. A role for pancreatic polypeptide in feeding and body weight regulation.

Kojima S, Ueno N, Asakawa A, Sagiyama K, Naruo T, Mizuno S, Inui A.

Peptides. 2007 Feb;28(2):459-63. Epub 2007 Jan 4. Review.


11. A motilin agonist, erythromycin, decreases circulating growth hormone levels in normal subjects but not in diabetic subjects.

Ueno N, Uemoto M, Komatsu Y, Sato Y, Inui A.

J Diabetes Complications. 2006 Nov-Dec;20(6):380-3.


12, Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin.

Boghossian S, Ueno N, Dube MG, Kalra P, Kalra S.

Neurobiol Aging. 2007 Oct;28(10):1594-604. Epub 2006 Sep 29.


13. Peptide YY3-36 and pancreatic polypeptide suppress food intake.

Asakawa A, Uemoto M, Ueno N, Katagi M, Fujimiya M, Fujino K, Kodama N, Nanba H, Sakamaki R, Shinfuku N, Meguid MM, Inui A.

J Gastroenterol Hepatol. 2006 Sep;21(9):1501-2. No abstract available.


14. Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice.

Ueno N, Inui A, Kalra PS, Kalra SP.

Peptides. 2006 Sep;27(9):2332-42. Epub 2006 Apr 18.


15. Mosapride improves food intake, while not worsening glycemic control and obesity, in ob/ob obese mice with decreased gastric emptying.

Asakawa A, Ueno N, Katagi M, Ijuin Y, Morita Y, Mizuno S, Inui T, Sakamaki R, Shinfuku N, Uemoto M.

J Diabetes Complications. 2006 Jan-Feb;20(1):56-8.


16. Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats.

Chen CY, Inui A, Asakawa A, Fujino K, Kato I, Chen CC, Ueno N, Fujimiya M.

Gastroenterology. 2005 Jul;129(1):8-25.


17. Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy.

Mizuno S, Morita Y, Inui T, Asakawa A, Ueno N, Ando T, Kato H, Uchida M, Yoshikawa T, Inui A.

Int J Cancer. 2005 Dec 20;117(6):1058-9.


18, Melanin-concentrating hormone enhances sucrose intake.

Sakamaki R, Uemoto M, Inui A, Asakawa A, Ueno N, Ishibashi C, Hirono S, Yukioka H, Kato A, Shinfuku N, Kasuga M, Katsuura G.

Int J Mol Med. 2005 Jun;15(6):1033-9.


19. Stimulation of appetite by ghrelin is regulated by leptin restraint: peripheral and central sites of action.

Kalra SP, Ueno N, Kalra PS.

J Nutr. 2005 May;135(5):1331-5. Review.


20. Development of pancreatic islets in pancreatic polypeptide-overexpressing mice.

Yuzuriha H, Inui A, Asakawa A, Ueno N, Sakamaki R, Shinfuku N, Kasuga M, Fujimiya M.

Int J Mol Med. 2004 Aug;14(2):201-5.


21. Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy.

Ueno N, Dube MG, Inui A, Kalra PS, Kalra SP.

Endocrinology. 2004 Sep;145(9):4176-84. Epub 2004 May 20.


22. Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice.

Sainsbury A, Baldock PA, Schwarzer C, Ueno N, Enriquez RF, Couzens M, Inui A, Herzog H, Gardiner EM.

Mol Cell Biol. 2003 Aug;23(15):5225-33.


23. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance.

Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M, Fujino MA, Niijima A, Meguid MM, Kasuga M.

Gastroenterology. 2003 May;124(5):1325-36.


24. ob/ob mice as a model of delayed gastric emptying.

Asakawa A, Inui A, Ueno N, Makino S, Uemoto M, Fujino MA, Kasuga M.

J Diabetes Complications. 2003 Jan-Feb;17(1):27-8.


25. Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels.

Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS, Kalra SP.

Diabetes. 2002 Jun;51(6):1729-36.


26. Impaired glucose tolerance in pancreatic polypeptide-overexpressing mice.

Ueno N, Inui A, Asakawa A, Yuzuriha H, Kasuga M, Fujimiya M.

Diabetologia. 2002 Jul;45(7):1048-9. No abstract available.


27. Mosapride, a 5HT-4 receptor agonist, improves insulin sensitivity and glycaemic control in patients with Type II diabetes mellitus.

Ueno N, Inui A, Asakawa A, Takao F, Komatsu Y, Kotani K, Nishimura R, Kasuga M.

Diabetologia. 2002 Jun;45(6):792-7. Epub 2002 May 15.


28. Erythromycin administration before sleep is effective in decreasing fasting hyperglycemia in type 2 diabetic patients.

Ueno N, Inui A, Asakawa A, Takao F, Ichibangase A, Komatsu Y, Kasuga M.

Diabetes Care. 2001 Mar;24(3):607. No abstract available.


29. Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding.

Kaga T, Inui A, Okita M, Asakawa A, Ueno N, Kasuga M, Fujimiya M, Nishimura N, Dobashi R, Morimoto Y, Liu IM, Cheng JT.

Diabetes. 2001 May;50(5):1206-10.


30. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin.

Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M.

Gastroenterology. 2001 Feb;120(2):337-45.


31. Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice.

Asakawa A, Inui A, Yuzuriha H, Nagata T, Kaga T, Ueno N, Fujino MA, Kasuga M.

Horm Metab Res. 2001 Sep;33(9):554-8.


32. Urocortin reduces oxygen consumption in lean and ob/ob mice.

Asakawa A, Inui A, Ueno N, Makino S, Fujimiya M, Fujino MA, Kasuga M.

Int J Mol Med. 2001 May;7(5):539-41.


33. Erythromycin improves glycaemic control in patients with Type II diabetes mellitus.

Ueno N, Inui A, Asakawa A, Takao F, Tani S, Komatsu Y, Itoh Z, Kasuga M.

Diabetologia. 2000 Apr;43(4):411-5.


34. Endomorphin-1, an endogenous mu-opioid receptor-selective agonist, stimulates oxygen consumption in mice.

Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino MA, Kasuga M.

Horm Metab Res. 2000 Feb;32(2):51-2.


35. Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice.

Ueno N, Inui A, Iwamoto M, Kaga T, Asakawa A, Okita M, Fujimiya M, Nakajima Y, Ohmoto Y, Ohnaka M, Nakaya Y, Miyazaki JI, Kasuga M.

Gastroenterology. 1999 Dec;117(6):1427-32.


36. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice.

Asakawa A, Inui A, Ueno N, Makino S, Fujino MA, Kasuga M.

Gastroenterology. 1999 Jun;116(6):1287-92.


37. Intracerebroventricularly administered corticotropin-releasing factor inhibits food intake and produces anxiety-like behaviour at very low doses in mice.

Momose K, Inui A, Asakawa A, Ueno N, Nakajima M, Fujimiya M, Kasuga M.

Diabetes Obes Metab. 1999 Sep;1(5):281-4.


38. Anxiolytic effect of motilin and reversal with GM-109, a motilin antagonist, in mice.

Momose K, Inui A, Asakawa A, Ueno N, Nakajima M, Kasuga M.

Peptides. 1998;19(10):1739-42.


39. Anxiety-like behavior in transgenic mice with brain expression of neuropeptide Y.

Inui A, Okita M, Nakajima M, Momose K, Ueno N, Teranishi A, Miura M, Hirosue Y, Sano K, Sato M, Watanabe M, Sakai T, Watanabe T, Ishida K, Silver J, Baba S, Kasuga M.

Proc Assoc Am Physicians. 1998 May-Jun;110(3):171-82.


40. Neuropeptide Y produces anxiety via Y2-type receptors.

Nakajima M, Inui A, Asakawa A, Momose K, Ueno N, Teranishi A, Baba S, Kasuga M.

Peptides. 1998;19(2):359-63.


41. Effect of the Kobe earthquake on stress and glycemic control in patients with diabetes mellitus.

Inui A, Kitaoka H, Majima M, Takamiya S, Uemoto M, Yonenaga C, Honda M, Shirakawa K, Ueno N, Amano K, Morita S, Kawara A, Yokono K, Kasuga M, Taniguchi H.

Arch Intern Med. 1998 Feb 9;158(3):274-8.


42. Motilin increases food intake in mice.

Asakawa A, Inui A, Momose K, Ueno N, Fujino MA, Kasuga M.

Peptides. 1998;19(6):987-90.


43. Endomorphins have orexigenic and anxiolytic activities in mice.

Asakawa A, Inui A, Momose K, Ueno N, Fujino MA, Kasuga M.

Neuroreport. 1998 Jul 13;9(10):2265-7.


44. Development of flexible ventriculoscope (Yamadori-type VII) and its application to experimental animals.

Inui A, Kamikawa S, Miyake S, Yamamoto K, Momose K, Ueno N, Nakajima M, Baba S, Kasuga M, Tamaki N, Yamadori T.

J Neurosci Methods. 1997 Jul 18;75(1):1-3.


45. Rebound hypoglycaemia after intravenous glucose in anorexia nervosa.

Inui A, Uemoto M, Seki W, Ueno N, Morita S, Baba S, Kasuga M.

Lancet. 1996 Feb 3;347(8997):323-4. No abstract available.


46. EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion.

Okano H, Inui A, Ueno N, Morimoto S, Ohmoto A, Miyamoto M, Aoyama N, Nakajima Y, Baba S, Kasuga M.

Peptides. 1996;17(6):895-900.


47. Dynorphin binds to neuropeptide Y and peptide YY receptors in human neuroblastoma cell lines.

Miura M, Inui A, Sano K, Ueno N, Teranishi A, Hirosue Y, Nakajima M, Okita M, Togami J, Koshiya K, et al.

Am J Physiol. 1994 Nov;267(5 Pt 1):E702-9.

糖尿病について

近年どうして糖尿病が増加しているのでしょうか? 食事をすると血糖値が上昇し、膵臓から血糖を下げるホルモンであるインスリンが血中に分泌されます。このインスリンが体の細胞に作用することによって・・・

続きを読む

糖尿病と糖尿病予備軍

現在日本の糖尿病人口は1000万人を超えていると推定されています。また、メタボリックシンドロームについてもその数は増加しており、メタボリックシンドロームとその予備軍も含めると2000万人を超えると・・・

続きを読む

院長プロフィール

日本糖尿病学会認定糖尿病専門医
日本内科学会認定総合内科専門医

続きを読む

院長の業績

Contribution of Leptin to Energy Expenditure and Glucose Metabolism in Fasting.・・・

続きを読む

学会活動

海外の学会
4th International Conference on Prehypertension, Hypertension・・

続きを読む

お気軽にお電話ください。

受付時間:9:00~11:30、および15:00~17:30
休診日:日曜、月曜、祝日、水曜・土曜の午後は休診
当院は、基本的に予約制となっています。